Alzheimer's disease is one of the most notorious neurodegenerative diseases, affecting tens of millions of people worldwide. It is characterized by progressive memory loss, cognitive decline, and behavioral changes due to the accumulation of amyloid plaques and tau tangles in the brain. These abnormal protein deposits disrupt the communication between neurons, ultimately leading to their death. The disease predominantly affects older adults, though early-onset Alzheimer's can strike individuals as young as in their 30s or 40s. As the population ages, Alzheimer's is expected to become more prevalent, posing significant challenges for healthcare systems and families alike. Current treatments focus on managing symptoms, but ongoing research aims to find more effective therapies and potential cures to alleviate the growing burden of this devastating condition.
Through decades of well-funded research, studies have identified various risk factors for Alzheimer's disease, shedding light on its complex etiology. Age is the most significant risk factor, with the likelihood of developing Alzheimer's increasing substantially after the age of 65. Genetics also play a crucial role, particularly the presence of the APOE-e4 allele, which has been linked to a higher risk of the disease. Other factors, such as a history of cardiovascular issues, hypertension, diabetes, and obesity, have been associated with an elevated risk. Additionally, lifestyle factors, including physical inactivity, poor diet, smoking, and low levels of cognitive engagement, can contribute to the development of Alzheimer's.
Although all of these risk factors play a significant role, genetic risk factors are arguably the most well-researched. So far, studies have identified tens of genes that play a significant role in the development of the disease. This information could save countless lives as a result of earlier treatment if it was more accessible. Currently getting a genetic risk assessment requires meeting with your primary care physician, getting redirected to a geneticist, who then has to order the test, and all the while you rack up an enormous insurance bill. However, Nyural is here to change that. Through a simple, quick, and affordable test, we can provide you with a risk assessment leveraging technology that hospitals don't have the time to invest in.